New polylactic acid preparation for fracture fixation

May 3 from the Langfang high-tech press conference was informed by the Nankai University as the "biodegradable fracture internal fixation screw" subject, using domestic L-lactic acid as raw materials, to prepare a fractured internal fixation screws that can replace metal materials. After several years of hard work, the project has achieved phased results.
Researchers first used L-lactic acid as raw material to make L-lactide, and then started ring-opening polymerization under the induction of stannous isooctoate to synthesize poly-L-lactic acid with high molecular weight.
Poly-L-lactic acid material has good biocompatibility, biodegradability and bioabsorbability, and can be degraded and absorbed in human body. Because the high molecular weight poly-L-lactic acid has good mechanical strength and is in good agreement with the strength of human bones, fractured internal fixators or degradable sutures prepared using this type of material can eventually be absorbed by the body, avoiding secondary effects. Extra pain caused by surgery. In addition, some of the more toxic, easily decomposed drugs or very expensive drugs can be encapsulated using poly-L-lactic acid or its copolymers to make injectable microspheres, so that the release rate of the drug in the human body is controlled, and the drug is increased. Bioavailability. It is understood that the tin oxide octoate contained in the poly L-lactic acid has passed the inspection of the US Food and Drug Administration (FDA) and has no toxic side effects on the human body.
After the technology is industrialized and applied, the product can be applied in fields such as bioengineering, medicine, and medical equipment. At the same time, various drug controlled release agents can be developed to reduce the toxic side effects of drugs and improve the bioavailability of drugs. In addition, with the gradual expansion of polylactic acid production and cost reduction, the downstream products of polylactic acid will be further developed and utilized.

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